Description
What is 5F-AKB48?
5F-AKB48 is a synthetic cannabinoid from the indazole-3-carboxamide family, designed to mimic the effects of THC (the active compound in cannabis). It acts as a potent agonist at the CB1 and CB2 receptors, producing psychoactive effects. However, it is significantly more dangerous than natural cannabis due to its unpredictable potency and side effects.
Key Facts:
- Chemical Name: N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide
- Class: Synthetic cannabinoid (SC)
- Potency: Much stronger than natural THC, increasing overdose risks
- Common Forms: Powder, herbal blends (“spice”), or e-liquids
Effects of 5F-AKB48
Short-Term Effects:
- Euphoria and relaxation (similar to cannabis)
- Altered perception and mild hallucinations
- Increased heart rate and blood pressure
- Anxiety, paranoia, or panic attacks
- Nausea and vomiting
- Seizures (in high doses)
Long-Term Risks:
- Dependence & withdrawal symptoms (insomnia, irritability, cravings)
- Psychosis (with heavy or prolonged use)
- Heart damage (due to extreme cardiovascular stress)
- Cognitive impairment (memory and concentration issues)
Dosage & Administration
- No safe dosage has been established due to extreme variability in potency.
- Often sold as “herbal blends” or “liquid for vaping”, making dosing unreliable.
- Even small amounts can lead to overdose or severe side effects.
Dangers & Overdose Risks
5F-AKB48 is associated with:
- Severe tachycardia (dangerously high heart rate)
- Hypertension (risk of stroke or heart attack)
- Seizures (even in healthy individuals)
- Psychotic episodes (especially in predisposed users)
- Fatalities (linked to respiratory depression or cardiac arrest)
Signs of Overdose:
- Extreme confusion or agitation
- Chest pain or irregular heartbeat
- Unconsciousness or difficulty breathing
- Seizures
If overdose is suspected, seek emergency medical help immediately.
Harm Reduction Tips
- Avoid use entirely—synthetic cannabinoids are extremely risky.
- Never mix with alcohol, stimulants, or depressants (increases overdose risk).
- Use reagent tests (if obtained in powder form) to verify substance.
- Have naloxone available (some synthetic cannabinoids interact with opioid receptors).
Legal Status
5F-AKB48 is ilgal in most countries due to its high abuse potential and health risks:
- USA: Schedule I under the Controlled Substances Act (CSA).
- UK: Class B under the Misuse of Drugs Act.
- Australia: Listed as a prohibited substance.
- EU: Banned under synthetic drug legislation.
Conclusion
5F-AKB48 is a dangerous synthetic cannabinoid with unpredictable effects and severe health risks. Due to its association with overdoses, psychosis, and fatalities, avoiding use is strongly recommended. If you or someone you know is struggling with substance use, seek professional help or harm reduction resources.






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