Fenortho

Description

Fenortho, also known as fenoprofen, is a non-steroidal anti-inflammatory drug (NSAID) primarily use for the relief of mild to moderate pain and for managing symptoms associated with rheumatoid arthritis and osteoarthritis. It was first approved in the United States in 1982 and is available in various oral capsule strengths, including 200 mg, 300 mg, and 400 mg.

Indications and Dosage

Fenortho is indicate for:

• Pain Relief: Effective for treating mild to moderate pain, with a recommended dosage of 200 mg every 4 to 6 hours as needed.
• Arthritis Management: For rheumatoid arthritis and osteoarthritis, the typical dosage ranges from 400 to 600 mg taken orally three to four times daily, not exceeding a total of 3,200 mg per day. The dosage may be adjusted based on individual patient needs and symptom severity.

Mechanism of Action

Fenoprofen works by inhibiting the synthesis of prostaglandins, which are chemicals in the body responsible for pain and inflammation. This action helps reduce pain intensity and inflammation in conditions such as arthritis.

Side Effects and Warnings

While Fenortho is effective for pain management, it carries significant risks:

• Cardiovascular Risks: There is an increased risk of serious cardiovascular events such as myocardial infarction and stroke, particularly with prolonged use1.
• Gastrointestinal Risks: Patients may experience gastrointestinal issues, including bleeding, ulceration, or perforation of the stomach or intestines. The risk is higher in elderly patients or those with a history of peptic ulcer disease.

Common side effects include:

• Upset stomach
• Headache
• Drowsiness
• Nausea

Patients are advised to use the lowest effective dose for the shortest duration necessary to minimize risks.

Clinical Efficacy

Clinical studies have demonstrated that fenoprofen is comparable to other NSAIDs like aspirin in managing pain and inflammation associated with arthritis. It has shown effectiveness in improving grip strength and reducing joint swelling among patients with rheumatoid arthritis. In acute postoperative settings, a single dose of fenoprofen has been reported to provide satisfactory pain relief comparable to ibuprofen.