Fenopron

Description

Fenopron, also known as fenoprofen calcium, is a nonsteroidal anti-inflammatory drug (NSAID) primarily use for the relief of mild to moderate pain, as well as for treating symptoms associated with rheumatoid arthritis and osteoarthritis. It operates by inhibiting the synthesis of prostaglandins, which are chemicals in the body that promote inflammation, pain, and fever.

Indications and Usage

Fenopron is indicate for:

• Pain Relief: Effective for mild to moderate pain.
• Rheumatic Conditions: Use in managing rheumatoid arthritis and osteoarthritis.
• Postoperative Pain: Demonstrate efficacy in acute postoperative pain management.

Pharmacology

Fenopron is a propionic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. Its mechanism of action involves the inhibition of cyclooxygenase (COX) enzymes, specifically reducing the production of prostaglandins. This results in decreased inflammation and pain perception.

Dosage

• Typical Dosage: 300 to 600 mg taken three to four times daily.
• Maximum Daily Dose: Should not exceed 3 g (UK) or 3.2 g (USA).
• Onset of Action: Peak plasma concentrations occur 1 to 2 hours post-administration.

Side Effects

Common side effects include:

• Gastrointestinal issues like nausea, heartburn, and constipation.
• Central nervous system effects such as headache and drowsiness.
  Serious side effects may require immediate medical attention but are less common.

Contraindications

Fenopron should not be used in patients with:

• Significant renal impairment.
• Known hypersensitivity to fenoprofen or other NSAIDs.
• History of asthma or allergic-type reactions after taking aspirin or similar medications.

Fenopron is available under various brand names, including Nalfon and Fenopron, although some formulations may be discontinued. It is important for users to consult healthcare providers for appropriate dosing and potential interactions with other medications.